Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats


Izzettin F. V. , SANCAR M. , OKUYAN B. , Apikoglu-Rabus S. , Cevikbas U.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.64, no.4, pp.339-343, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.etp.2010.09.007
  • Title of Journal : EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Page Numbers: pp.339-343
  • Keywords: Indomethacin-induced gastric ulcer, Omeprazole, Misoprostol, Ranitidine, Bismuth, Rat, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, OMEPRAZOLE, MISOPROSTOL, PREVENTION, CIMETIDINE, SUCRALFATE, ASPIRIN, THERAPY

Abstract

The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol)alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats.