Evaluation of the Effects of Donepezil, Memantine and alpha-lipoic Acid Combined Administration in Amnesia Rats on Impaired Cognitive Functions in Terms of Behavioural, Apoptotic, Cholinergic and Glutamatergic Systems


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Aykac A., ÖZBEYLİ D. , Pekol G., Sehirli A. O.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.11, no.4, pp.733-741, 2021 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.33808/clinexphealthsci.856459
  • Title of Journal : CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Page Numbers: pp.733-741
  • Keywords: Alpha-lipoic acid, amnesia, apoptosis, scopolamine, Y-maze, INDUCED MEMORY IMPAIRMENT, NEUROTROPHIC FACTOR, MUSCARINIC RECEPTORS, OXIDATIVE STRESS, SUBTYPES, MODEL, INFLAMMATION, ANTIOXIDANT, HIPPOCAMPUS, MECHANISMS

Abstract

Objective: The aim of the study was to evaluate the possible protective effect of donepezil, memantine and alpha-lipoic acid (alpha-LA) combined therapy in the scopolamine-induced amnesia rat model.