Effects of caffeic acid phenethyl ester on lipopolysaccharide-induced lung injury in rats

KÖKSEL M. O., ÖZDÜLGER A., TAMER L., CİNEL Z. L., Ercil M., Değirmenci U., ...More

PULMONARY PHARMACOLOGY & THERAPEUTICS, vol.19, no.2, pp.90-95, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.pupt.2005.03.006
  • Journal Name: PULMONARY PHARMACOLOGY & THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.90-95
  • Keywords: caffeic acid phenethyl ester, endotoxin-induced lung injury, lipopolysaccharide, N-ACETYLCYSTEINE, NITRIC-OXIDE, PROPOLIS, ENDOTOXIN, PEROXYNITRITE, CAPE, INFLAMMATION, NEUTROPHILS, MECHANISMS, COMPONENTS
  • Marmara University Affiliated: No

Abstract

Extracts of propolis, a natural beehive product, have been known for centuries to have a variety of beneficial medical properties, among which their anti-inflammatory effect is a major one. Caffeic acid phenethyl ester (CAPE), an active propolis component, has antimicrobial, anti-inflammatory, antioxidant, carcinostatic and immunomodulatory properties. In this study, we aimed to investigate the efficacy of CAPE in endotoxin-induced lung injury in rats.