Paraneoplastic pandysautonomia as a manifestation of non-small cell lung cancer

ULUÇ K. , Kocak M., KAHRAMAN KOYTAK P. , Borucu D., Isak B., Aktan S., ...More

NEUROLOGICAL SCIENCES, vol.31, no.6, pp.813-816, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1007/s10072-010-0288-3
  • Title of Journal : NEUROLOGICAL SCIENCES
  • Page Numbers: pp.813-816


Pandysautonomia is a severe and rare clinical condition characterized by widespread sympathetic and parasympathetic dysfunction. Consideration of whether symptoms and presentation are acute, subacute, or chronic is often helpful in establishing a differential diagnosis. The underlying mechanisms leading to pure pandysautonomia are unclear; however, there is some evidence suggestive of an immune-mediated pathogenesis. Herein, we report a case with pandysautonomia as a paraneoplastic manifestation of non-small cell lung cancer that had an excellent response to symptomatic and supportive treatments, as well as IVIG therapy.