Histomorphological Changes of Apelin Treatment in Renal Tissue in Doxorubicin-induced Nephrotic Syndrome Model


ÖZKAN N. , Sehirli A. O. , KOÇ M. , ÇETİNEL Ş.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.6, no.1, pp.20-27, 2016 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5152/clinexphealthsci.2016.060
  • Title of Journal : CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Page Numbers: pp.20-27

Abstract

Objective: Nephrotic syndrome (NS) may result in renal failure. Apelin (AP), a vasoactive peptide, demonstrates its effect by binding to the AP receptor. AP, present in the endothelial and vascular smooth muscle cells of glomerular arterioles, affects the pre- and post-microvascularization by regulating renal hemodynamics. This study aimed to determine the histomorphological changes of AP treatment in a doxorubicin (DOX)-induced NS model.