Effect of oral antiseptic agents on phospholipase and proteinase enzymes of Candida albicans


Uygun-Can B., KADİR T. , GÜMRÜ TARÇIN B.

ARCHIVES OF ORAL BIOLOGY, vol.62, pp.20-27, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62
  • Publication Date: 2016
  • Doi Number: 10.1016/j.archoralbio.2015.11.006
  • Title of Journal : ARCHIVES OF ORAL BIOLOGY
  • Page Numbers: pp.20-27
  • Keywords: Candida-associated denture stomatitis, Chlorhexidine, Hexetidine, Triclosan, Exoenzymes, BUCCAL EPITHELIAL-CELLS, GERM TUBE FORMATION, CHLORHEXIDINE GLUCONATE, IN-VITRO, SUBTHERAPEUTIC CONCENTRATIONS, VIRULENCE FACTORS, BRIEF EXPOSURE, SACCHAROMYCES-CEREVISIAE, DENTURE STOMATITIS, MOUTH RINSES

Abstract

Objective: Candida-associated denture stomatitis is the most prevalent form of oral candida infections among the denture wearers. Generally, antiseptic oral rinses used in the treatment of these infections are considered as an adjunct or alternative antifungal treatment. Studies have suggested that the intraoral concentrations of antiseptics decrease substantially to the sub-therapeutic levels on account of the dynamics of the oral cavity. This condition yields the question about the minimum antiseptic concentration that effect the character or pathogenesis of Candida during treatment. The extracellular phospholipase and proteinase enzymes of Candida albicans are regarded to have a crucial role in the pathogenesis of human fungal infections. Therefore, the aim of this study was to investigate the effect of different sub-therapeutic concentrations of chlorhexidine gluconate, hexetidine and triclosan on the production of these enzymes by C. albicans strains isolated from 20 patients with denture stomatitis.