Growth Arrest-Specific 6 (Gas6) and TAM Receptors in Mouse Platelets

Uras F., Kucuk B., BİNGÖL ÖZAKPINAR Ö., DEMİR A. M.

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.1, pp.58-63, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2013.0097
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.58-63
  • Keywords: Blood platelets, Growth arrest-specific protein 6, Hemostasis, VASCULAR SMOOTH-MUSCLE, TYROSINE KINASE, PROTEIN-S, EXPRESSION ANALYSIS, BLOOD-COAGULATION, ENDOTHELIAL-CELLS, AXL, GENE, MER, LIGAND
  • Marmara University Affiliated: Yes

Abstract

Objective: Growth arrest-specific 6 (Gas6) is a newly discovered vitamin K-dependent protein, which is a ligand for TAM receptors [Tyro3 (Sky), Axl, and Mer] from the tyrosine kinase family. Gas6 knockout mice were resistant to venous and arterial thrombosis. There are contradictory reports on the presence of Gas6 and its receptors in mouse platelets. The objective of this study was to investigate whether Gas6 and its receptors were present in mouse platelets or not.