Growth Arrest-Specific 6 (Gas6) and TAM Receptors in Mouse Platelets


Uras F., Kucuk B., BİNGÖL ÖZAKPINAR Ö., DEMİR A. M.

TURKISH JOURNAL OF HEMATOLOGY, cilt.32, sa.1, ss.58-63, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/tjh.2013.0097
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.58-63
  • Anahtar Kelimeler: Blood platelets, Growth arrest-specific protein 6, Hemostasis, VASCULAR SMOOTH-MUSCLE, TYROSINE KINASE, PROTEIN-S, EXPRESSION ANALYSIS, BLOOD-COAGULATION, ENDOTHELIAL-CELLS, AXL, GENE, MER, LIGAND
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Growth arrest-specific 6 (Gas6) is a newly discovered vitamin K-dependent protein, which is a ligand for TAM receptors [Tyro3 (Sky), Axl, and Mer] from the tyrosine kinase family. Gas6 knockout mice were resistant to venous and arterial thrombosis. There are contradictory reports on the presence of Gas6 and its receptors in mouse platelets. The objective of this study was to investigate whether Gas6 and its receptors were present in mouse platelets or not.