CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.25, no.11, pp.908-912, 1998 (Journal Indexed in SCI)
Article / Article
Title of Journal :
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
chemiluminescence, mesenteric ischaemia/reperfusion, nitric oxide, reactive oxygen species, superoxide radical, thiobarbituric acid-reactive substances, SUPEROXIDE, INJURY, PEROXYNITRITE
1. The aims of the present study were to detect changes in superoxide anion (O-2(.-)), nitric oxide (NO) and other reactive oxygen species (ROS) directly by measurement of chemiluminescence (CL) and to investigate the role of L-arginine, a nitric oxide synthase (NOS) substrate, and N-G-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, together with their molecular enantiomers D-arginine and D-NAME, in a rat mesenteric ischaemia-reperfusion (I/R) model.