HER-2 incidence in gastric cancer, its association with prognosis and clinicopathological parameters

UPRAK T. K., Attaallah W., ÇELİKEL Ç., Ayranci G., Yegen C.

TURKISH JOURNAL OF SURGERY, cilt.31, sa.4, ss.207-213, 2015 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/ucd.2015.2964
  • Dergi Adı: TURKISH JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.207-213
  • Anahtar Kelimeler: HER-2, gastric cancer, prognosis, C-ERBB-2 PROTEIN EXPRESSION, GENE AMPLIFICATION, SURVIVAL, OVEREXPRESSION, ADENOCARCINOMA, TRASTUZUMAB, RESECTION, MARKER, IMPACT
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Human epidermal growth factor-2 (HER-2) overexpression has prognostic value in breast cancer. However, the significance of HER-2 positivity in gastric cancer is controversial. In this study, we investigated the frequency of overexpression of HER-2 and its relationship with clinicopathological findings and impact on survival in gastric cancer.