In vitro electrically controlled amoxicillin release from 3D-printed chitosan/bismuth ferrite scaffolds

Baykara D., Pilavci E., Ulag S., Okoro O. V., Nie L., Shavandi A., ...More

European Polymer Journal, vol.193, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 193
  • Publication Date: 2023
  • Doi Number: 10.1016/j.eurpolymj.2023.112105
  • Journal Name: European Polymer Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: 3D printing, Amoxicillin, Bismuth ferrite, Chitosan, Controlled drug delivery, Scaffold
  • Marmara University Affiliated: Yes


The goal of this study was to design and fabricate a 3D-printed wound dressing using chitosan as a bioink, with the ability to release the antibiotic drug amoxicillin (AMX) in response to mild electrical stimulation. This was achieved through the incorporation of bismuth ferrite (BFO) nanoparticles, which have both magnetic and ferroelectric properties. The chitosan-based scaffolds containing various concentrations of BFO were analyzed using Fourier transform infrared spectroscopy, and the release of AMX from the scaffolds was evaluated in vitro under electrical stimulation. The results demonstrated that the scaffolds had a suitable structure for drug loading and release, and the release of AMX was successfully controlled by the applied electrical stimulus. The maximum tensile strength (4.97 ± 0.34 MPa) was observed at the ratio of 6% CHT/0.025% BFO scaffolds and the scaffold with 6% CHT/0.075% BFO had the maximum cell viability of (∼130%) at 168 h incubation time. This study highlights the potential of BFO to deliver therapeutic drugs from a 3D-printed chitosan scaffold in a controlled manner.