Apocrine carcinomas of the breast in Turkish women: Hormone receptors, c-erbB-2 and p53 immunoexpression


KAYA H. , Bozkurt S. , ERBARUT SEVEN İ. , Djamgoz M. B. A.

PATHOLOGY RESEARCH AND PRACTICE, vol.204, no.6, pp.367-371, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 204 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1016/j.prp.2008.01.012
  • Title of Journal : PATHOLOGY RESEARCH AND PRACTICE
  • Page Numbers: pp.367-371
  • Keywords: apocrine carcinoma, breast, hormone receptor, oncogene, PROGESTERONE-RECEPTOR, ESTROGEN-RECEPTOR, IMMUNOHISTOCHEMICAL ANALYSIS, ANDROGEN RECEPTORS, EXPRESSION, MUTATIONS, FREQUENCY, PATHOLOGY, CANCER, AGE

Abstract

The aims of this study were twofold: (i) to determine the occurrence frequency of apocrine carcinoma of the breast (ApBCa) in Turkish breast cancer (BCa) patients; and (ii) to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), gross cystic disease protein-15 (GCDFP-15), c-erbB-2, and p53 in these cases. Six hundred and twenty-six cases of BCa were studied immunohistochemically (streptoavidin-biotin horseradish peroxidase method). The results of ApBCa were compared with those of invasive ductal carcinoma not otherwise specified type (IDC-NOS) cases of similar grade. Thirteen cases of ApBCa were encountered, accounting for 2.1% of all BCa cases. Immunohistochemically, ApBCa positivity was as follows: GCDFP-15 (100%), ER (39%), PR (8%), AR (54%), p53 (39%), and c-erbB-2 (85%). In the IDC-NOS group, GCDFP-15* was expressed in less than 50% of the tumors. The occurrence frequencies of the other markers were as follows: ER (69%), PR (69%)*, AR (46%), c-erbB-2 (0%)*, and p53 (31%), (*) indicating significant differences between the two groups.