Octreotide improves burn-induced intestinal injury in the rat

Sener G. , Sehirli A., Satiroglu H., Kacmaz A., Ayanoglu-Dulger G., Yegen B.

PEPTIDES, vol.24, no.1, pp.123-127, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1016/s0196-9781(02)00284-x
  • Title of Journal : PEPTIDES
  • Page Numbers: pp.123-127


The local thermal trauma activates a number of systemic mediator cascades, e.g. a complement activation, cytokine production, resulting in a generalized sequestration and a priming of local and systemic neutrophils and macrophages. We aimed to determine the possible protective effect of octreotide (OCT), a synthetic somatostatin analogue, against burn-induced intestinal tissue damage possibly by inhibiting neutrophil infiltration.