Research Information System
Şahin A., Kaptanoğlu E.(Executive), Güvenç Y., Atasoy B. M., Bozkurt S., Pınar E.
Project Supported by Higher Education Institutions, BAP Research Project, 2016 - 2018
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Project Summary As
clinical outcome of acute traumatic spinal cord injury, many person is forced
to sustain with paralysis their lives. These patiens which are very difficult
medical and social care are faced with many complications over the years. Acute
traumatic spinal cord injury patients and their families bring spiritual
material loads too heavy. After
the trauma of the spinal cord was injured by the impact, damage advances in
the hours and within days, and may cause patients to be clinically worse. A
treatment to prevent this progressive damage that is defined as collateral
damage had not been found yet. Although many of the promising results of
laboratory research conducted to date, none of these studies could not find
no chance to clinical practice. Because many complex mechanisms involved in
the pathophysiology of traumatic spinal cord injury received is thrown to the
forefront the idea of combination therapy in recent years. Therefore, in our
study, the treatment of traumatic spinal cord injury is planned to be used
two different modalities together. These are combined with erythropoietin and
ionizing radiation therapy. In this study, to see the individual effects of
each treatment is vital in assesing the effects of the combined treatment.
For this purpose, both alone and in combination therapy are planned to be
implemented. As a
result of the conduct of this study, the reduction and prevention of spinal
cord injury in humans and ultimately clinical improvement is expected. The
main reason for this study has been done in animals can be simulate as human
spinal cord injury which is complex injury. However, thanks to these models,
especially developed using clinical assesment methods in rats, allow clinical
imrovement assessed. Folloving the evaluation of the results of erydhropoietin and low doses of ionizing radiation to be effective in the combined treatment of acute spinal cord injury, for clinical treatments by making the most effective dose and the most effective time to research studies are planned. This study, planned similar issues in our instituion, is expected to form the basis of the cell, tissue, animal and human studies. Keywords: Spinal Cord Injury,
Erythropoietin, Ionizing Radiation |