Omurilik Yaralanmasında Travma Sonrası Erken Dönemde Uygulanan Düşük Doz İyonize Radyasyon ve Eritropoietinin Sekonder Hasarın Önlenmesinde Etkisinin İncelenmesi

Şahin A. , Kaptanoğlu E.(Executive), Güvenç Y. , Atasoy B. M. , Bozkurt S. , Pınar E.

Project Supported by Higher Education Institutions, 2016 - 2018

  • Project Type: Project Supported by Higher Education Institutions
  • Begin Date: October 2016
  • End Date: November 2018

Project Abstract

Project Summary

As clinical outcome of acute traumatic spinal cord injury, many person is forced to sustain with paralysis their lives. These patiens which are very difficult medical and social care are faced with many complications over the years. Acute traumatic spinal cord injury patients and their families bring spiritual material loads too heavy.


After the trauma of the spinal cord was injured by the impact, damage advances in the hours and within days, and may cause patients to be clinically worse. A treatment to prevent this progressive damage that is defined as collateral damage had not been found yet. Although many of the promising results of laboratory research conducted to date, none of these studies could not find no chance to clinical practice. Because many complex mechanisms involved in the pathophysiology of traumatic spinal cord injury received is thrown to the forefront the idea of combination therapy in recent years. Therefore, in our study, the treatment of traumatic spinal cord injury is planned to be used two different modalities together. These are combined with erythropoietin and ionizing radiation therapy. In this study, to see the individual effects of each treatment is vital in assesing the effects of the combined treatment. For this purpose, both alone and in combination therapy are planned to be implemented.


As a result of the conduct of this study, the reduction and prevention of spinal cord injury in humans and ultimately clinical improvement is expected. The main reason for this study has been done in animals can be simulate as human spinal cord injury which is complex injury. However, thanks to these models, especially developed using clinical assesment methods in rats, allow clinical imrovement assessed.


Folloving the evaluation of the results of erydhropoietin and low doses of ionizing radiation to be effective in the combined treatment of acute spinal cord injury, for clinical treatments by making the most effective dose and the most effective time to research studies are planned. This study, planned similar issues in our instituion, is expected to form the basis of the cell, tissue, animal and human studies.

Keywords: Spinal Cord Injury, Erythropoietin, Ionizing Radiation