Akademik Veri Yönetim Sistemi
Yükseköğretim Kurumları Destekli Proje, 2012 - 2013
Aims: This
study was to investigate the effects of local ad- ministration of gamma-aminobutyric acid (GABA) agonists into the nucleus accumbens (NAc) on
naloxone-induced morphine withdrawal
symptoms. Methods: Bilateral
guide cannulas were stereotaxically
implanted in the shell or core regions of the NAc of Sprague-Dawley rats. After a recovery period, 3 morphine pellets, each
consisting of 75 mg mor- phine base, were placed subcutaneously on the first and third days of the study with the rats under mild ether anaes-
thesia. The GABA agonists,
baclofen hydrochloride or musci- mol
hydrobromide, were injected into the NAc, and mor- phine withdrawal was induced
by naloxone on the fifth day. Results:
Administration of baclofen to the shell or core
re- gions of the NAc of
Sprague-Dawley rats led to statistically significant decreases
in both behavioural and locomotor ac- tivity parameters during
the morphine withdrawal period, compared to the control group.
However, there were no sta-
tistically significant changes
in locomotor activity
or with- drawal
behavioural parameters, with the exception of wet dog shakes,
between control and muscimol-treated groups