Akademik Veri Yönetim Sistemi
Süsleyici B. (Yürütücü)
TÜBİTAK Projesi, 2219 - Yurt Dışı Doktora Sonrası Araştırma Burs Programı, 2025 - 2025
The results of our study describe how
frequent blood donation changes the hematopoietic stem cell (HSC) landscape,
evidenced by positive selection of HSC clones carrying particular mutations
associated with distinct systemic stresses. This study generated a reference CH
dataset from a population of exclusively healthy older individuals. Our
findings highlight ongoing Darwinian evolution at the HSC level in frequent
blood donors, with EPO emerging as a novel environmental factor that favors
HSCs carrying specific DNMT3A mutations. One of the other most interesting findings
of this study was that specific DNMT3A mutations had distinct responses to
erythropoietin, highlighting a new and functionally distinct class of DNMT3A variants.
Specific DNMT3A mutations driving reduced enzymatic activity have been found to
provide HSCs with a selective advantage that manifests itself in the context of
increased EPO exposure. Shortly, creating a catalog of CH mutations together
with their unique triggers may help inform the therapeutic efforts in various diseases
where the mature blood cell progeny bearing CH mutations may be influencing the
immune cell microenvironment.